There are many factors to consider after many failed IVF cycles, some f these are the quality of the egg, sperm and or embryo. The uterus and endometrıum lining is also a key to investigate after many failed IVF attempts.
The Uterus can be examined via Hysteroscopy as well an ultrasound. These techniques can detect whether there are any uterine fibroids, polyps, collapse of the uterine top wall etc. That is stopping the embryo from embedding; these can then be corrected and follow with another IVF cycle.
Studies conducted in recent years, have observed that the uterine tissue does not show synchronized development with the development of the embryo, if the embryo is ready for transfer but the uterine tissue does not reach a sufficient thickness level for implantation of the embryo (minimum 8mm) the chance of falling pregnant is decreased.
The ERA test, allows the uterine tissue to be examined and most importantly understand the appropriate period for the embryo transfer prior to in vitro fertilization treatment, it is an extremely advanced and new ground breaking genetic test.
It is now possible with the ERA test to predict whether the uterus would accept the embryos or not, or which day the embryo transfer should be carried out to increase the chance of pregnancy.
What is the potential benefit of ERA test in donation treatments?
Treatment success is dependent on the strength of the uterine tissue and its acceptance of the embryos more than the eggs, sperm individually as high quality embryos are used in donation treatments. The results obtained after the ERA test shows that pregnancy success could be further increased by treatment programs that determine the correct day of embryo transfer, if necessary, changing the transfer day is key in giving patients the highest chance or falling pregnant. It is also possible to learn about the causes of previously failed / negative IVF attempts according to the results obtained with the ERA.
How is the ERA test performed?
The ERA test is an endometrial biopsy which is carried out on an induced or natural cycle. The small endometrial tissue obtained via biopsy is then sent for screening. Although obtaining tissue is a very simple process, it is performed in the operating room as this environment is highly sterile and a mild sedative for the comfort of the patient is also administered. The obtained tissue is analysed in detail, examining over 230 genes and gene products by using advanced molecular genetic diagnosis methods. The results take approximately 4 weeks to be known and determined when transfer is optimum, so treatment for a transfer can be planned accordingly.
It is extremely important to plan the test and treatment on frozen embryo transfers, in order to obtain maximum benefit from the ERA test by the candidate couples.
In other words, the ERA test is not an appropriate test for treatments that are planned fresh transfer after the egg collection procedure stimulated by hormones.
If high success cannot be achieved in a frozen embryo transfer after the ERA test is said to be performed at a clinic, couples have to remember that the benefits of ERA testing are limited to an extent.